NeuroClues

Captures and analyzes eye movement patterns (saccades, smooth pursuits, fixations, nystagmus) using infrared corneal reflection tracking at 60-250Hz sampling rates to quantify deviations from normative oculomotor baselines. The system applies machine learning classifiers trained on neurologically-healthy control populations to detect subclinical abnormalities in eye-movement kinematics that precede visible neurological symptoms, enabling detection of early-stage neurodegenerative conditions like Parkinson's, cerebellar ataxia, and progressive supranuclear palsy before conventional clinical signs emerge.

Stores baseline oculomotor metrics for individual patients and compares subsequent assessments against personalized baselines using statistical process control methods (e.g., exponentially-weighted moving average, control charts) to detect statistically-significant decline trajectories. The system generates alerts when oculomotor metrics deviate beyond patient-specific confidence intervals, enabling clinicians to quantify disease progression velocity and adjust therapeutic interventions based on objective biomarker trends rather than subjective symptom reports.

Integrates oculomotor metrics with optional supplementary neurological data (tremor accelerometry, gait kinematics, cognitive reaction times) into ensemble machine learning classifiers (random forests, gradient boosting, neural networks) trained on clinically-diagnosed patient cohorts to generate probabilistic diagnoses for specific neurological conditions. The system outputs condition-specific probability scores (e.g., 78% Parkinson's, 12% essential tremor, 10% other) with confidence intervals, enabling clinicians to rank differential diagnoses and prioritize confirmatory testing.

Captures raw eye-gaze coordinates and pupil diameter from infrared corneal reflection eye-tracker hardware at 60-250Hz sampling rates, applies real-time preprocessing (blink detection, saccade detection via velocity thresholding, fixation clustering, outlier removal) to clean noisy tracking data, and streams preprocessed gaze events to downstream analysis pipelines. The system implements hardware-specific calibration routines (9-point or 13-point grid calibration) and validates tracking quality metrics (gaze accuracy, precision, data loss rate) before accepting data for clinical analysis.

Implements standardized visual stimulus presentation sequences (fixation tasks, smooth pursuit tasks, saccadic tasks, optokinetic nystagmus tasks) with precise timing control and stimulus geometry to elicit reproducible oculomotor responses across patients and assessment sessions. The system presents calibrated visual targets at defined eccentricities and velocities, records stimulus timing metadata, and ensures consistent task execution across different clinical sites through protocol validation and technician training modules.

Compares individual patient oculomotor metrics against age-stratified, ethnicity-stratified normative reference databases using z-score calculations to quantify deviation magnitude from healthy population norms. The system applies demographic-specific normalization (accounting for age-related oculomotor decline, sex differences, ethnic variation) and generates percentile ranks and confidence intervals around deviation scores, enabling clinicians to interpret whether observed oculomotor abnormalities are statistically significant or within normal variation.

Exports oculomotor assessment results (metrics, diagnoses, longitudinal trends) in standardized clinical report formats compatible with electronic health record systems, including structured data fields (FHIR-compatible observations) and human-readable narrative summaries. The system generates PDF reports suitable for clinician review and EHR import, with embedded visualizations (metric trends, diagnostic probability charts) and recommendations for follow-up testing or therapeutic intervention.

Monitors eye-tracking data quality metrics in real-time (gaze accuracy, precision, data loss rate, tracking confidence) and flags assessment sessions with suboptimal data quality that may compromise diagnostic validity. The system implements automated quality checks (e.g., gaze accuracy >1.5 degrees triggers recalibration alert, data loss >10% triggers session rejection) and generates quality assurance reports documenting tracking performance and protocol compliance for each assessment session.

Provides structured training modules for eye-tracking technicians covering hardware operation, calibration procedures, patient interaction, protocol execution, and troubleshooting common tracking failures. The system includes competency assessment tools (simulated patient scenarios, calibration accuracy tests, protocol compliance quizzes) to validate technician proficiency before independent clinical assessment execution, with ongoing competency monitoring through quality assurance metrics.