Protein Activity And Function Prediction

via “structure-based functional annotation and motif detection”

* 📰 2022: [ChatGPT: Optimizing Language Models For Dialogue (ChatGPT)](https://openai.com/blog/chatgpt/)

Unique: Uses geometric hashing to detect structural motifs independent of sequence, enabling functional annotation of proteins with no sequence homologs. Combines spatial clustering with database matching to identify recurring 3D patterns at sub-domain resolution.

vs others: Complements sequence-based annotation (BLAST, Pfam) by identifying functional sites in proteins with low sequence identity but conserved structure; more sensitive to subtle structural similarities than RMSD-based methods.

via “protein-sequence-annotation-and-function-prediction”

A large language model for science. Can summarize academic literature, solve math problems, generate Wiki articles, write scientific code, annotate molecules and proteins, and more. [Model API](https://github.com/paperswithcode/galai).

via “bioactivity prediction for chemical structures”

via “protein-structure-prediction”

via “protein-structure-prediction”

via “biological-sequence-prediction”

via “molecular interaction prediction”

via “batch molecular property prediction”