glass.health

Accepts unstructured clinical presentation data (chief complaint, history of present illness, physical exam findings, lab results) and generates ranked differential diagnosis lists using LLM reasoning with embedded medical knowledge. The system processes free-text clinical narratives through prompt engineering that enforces structured diagnostic reasoning, prioritizing conditions by epidemiological likelihood and clinical relevance rather than simple keyword matching. Architecture relies on few-shot prompting with real clinical case examples to guide the LLM toward clinically sound differential generation.

For each differential diagnosis suggestion, the system generates a natural-language explanation of the clinical logic connecting the patient's presentation to the suggested condition. This works by prompting the LLM to explicitly state which clinical features (symptoms, signs, labs) support each diagnosis and how they align with epidemiological or pathophysiological patterns. The explanation layer enables clinicians to verify reasoning rather than blindly accepting suggestions, functioning as a transparency mechanism for AI-assisted decision-making.

Leverages the broad training data of large language models to surface rare diagnoses and complex condition combinations that might be overlooked in time-pressured clinical environments. The system works by encoding the patient presentation and allowing the LLM to generate differentials across its entire knowledge base without filtering to 'common' diagnoses. This is particularly effective for zebra cases, atypical presentations of common diseases, and rare genetic or infectious conditions where clinician familiarity is low.

Accepts free-text clinical narratives (chief complaint, history of present illness, physical exam notes, lab result descriptions) and processes them through the LLM to extract and normalize clinical information into a structured format suitable for diagnostic reasoning. The system uses prompt engineering to guide the LLM to identify key clinical features, temporal relationships, and severity indicators from unstructured text. This enables clinicians to input data in their natural documentation style without requiring structured data entry.

Provides diagnostic support at the moment of clinical decision-making through a web interface that requires manual input of clinical data rather than automatic EHR integration. The system is designed for rapid access and minimal setup—clinicians can open the tool, paste or type clinical information, and receive differential diagnoses within seconds. This architecture trades integration friction for deployment simplicity and avoids complex EHR API dependencies.

Provides full access to differential diagnosis generation and clinical reasoning explanations without requiring payment, subscription, or institutional licensing. The business model removes financial barriers to adoption, allowing individual clinicians to experiment with AI-assisted diagnostics regardless of their institution's budget or purchasing decisions. This is implemented through a freemium model where core diagnostic functionality is available without payment.

Accepts clinical data across multiple organ systems and integrates them into a unified differential diagnosis that considers multi-system involvement and systemic conditions. The system uses LLM reasoning to identify patterns that span multiple systems (e.g., fever + rash + joint pain + eye inflammation → systemic inflammatory condition) rather than generating separate differentials for each system. This enables consideration of connective tissue diseases, vasculitides, infections, and other conditions that present with multi-system involvement.